While pretty much everything else I've tried works, I've noticed some problems with video codecs and players. Playing XVid/DivX can be painful with the current breed of codecs and the latest 0.86 version of VLC has problems with MPEG2 (I get a green image only, using 0.85 it works, but turns off Aero for the screen VLC is on). But there are commercial MPEG2 codecs out there that are Vista compatible, so this is an instance of 3rd party/opensource software not quite keeping up.
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